Electrochemotherapy is a type of chemotherapy that allows delivery of non-permeant chemotherapy drugs to the cell interior. It is based on the local application of short and intense electric pulses that transiently permeabilize the cell membrane, thus allowing transport of molecules otherwise not permitted by the membrane. Applications for treatment of cutaneous...
In electrochemotherapy, the optimal antitumour effectiveness is achieved when electric pulses are given at the time of the highest extracellular concentration of hydrophilic chemotherapeutic drug in the tumour, thereby increasing their transport through the plasma membrane towards their intracellular targets.
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